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YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong
《医学前沿(英文)》 2007年 第1卷 第4期 页码 423-428 doi: 10.1007/s11684-007-0083-6
关键词: identical different teaching hospital genotype colistin-only-sensitive
Cholera: an overview with reference to the Yemen epidemic
Ali A. Rabaan
《医学前沿(英文)》 2019年 第13卷 第2期 页码 213-228 doi: 10.1007/s11684-018-0631-2
关键词: cholera epidemic multi-drug resistant catechin luteolin ToxT CTX&Fcy
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 182-188 doi: 10.1007/s11684-017-0529-4
With the abuse of antimicrobial agents in developing countries, increasing number of carbapenem-resistant Enterobacteriaceae (CRE) attracted considerable public concern. A retrospective study was conducted based on 242 CRE strains from a tertiary hospital in Hangzhou, China to investigate prevalence and drug resistance characteristics of CRE in southeast China. Bacterial species were identified. Antimicrobial susceptibility was examined by broth microdilution method or epsilometer test. Resistant β-lactamase genes were identified by polymerase chain reaction and sequencing. Genotypes were investigated by phylogenetic analysis. and were the most prevalent types of species, with occurrence in 71.9% and 21.9% of the strains, respectively. All strains exhibited high resistance (>70%) against β-lactam antibiotics, ciprofloxacin, trimethoprim–sulfamethoxazole, and nitrofurantoin but exhibited low resistance against tigecycline (0.8%) and minocycline (8.3%). A total of 123 strains harbored more than two kinds of β-lactamase genes. , , , and were the predominant genotypes, with detection rates of 60.3%, 61.6%, 43.4%, and 16.5%, respectively, and were highly identical with reference sequences in different countries, indicating potential horizontal dissemination. IMP-4 was the most frequent class B metallo-lactamases in this study. In conclusion, continuous surveillance and effective prevention should be emphasized to reduce spread of CRE.
关键词: Enterobacteriaceae carbapenem β-lactamase genes phylogenetic analysis
Development of a multi-component drug from turmeric using central composite design
Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 362-368 doi: 10.1007/s11705-014-1439-5
关键词: multi-component drug development central composite design turmeric curcuminoids
Solvent-resistant porous membranes using poly(ether−ether ketone): preparation and application
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1536-1559 doi: 10.1007/s11705-022-2221-8
关键词: PEEK phase inversion solvent-resistant membrane nanofiltration membrane contactor
Taking advantage of drug resistance, a new approach in the war on cancer
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 490-495 doi: 10.1007/s11684-018-0647-7
Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.
关键词: cancer drug resistance genetic screens senescence targeted therapy
Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems
Ranvijay KUMAR, Kaushlendra SHARMA
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 116-122 doi: 10.1007/s11705-013-1310-0
关键词: psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation
Protein microspheres for pulmonary drug delivery
Yongda SUN,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 82-86 doi: 10.1007/s11705-009-0307-1
关键词: advanced engineering improved pressure aqueous technique
Semi-solid materials for controlled release drug formulation: current status and future prospects
Michelle TRAN,Chun WANG
《化学科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 225-232 doi: 10.1007/s11705-014-1429-7
关键词: controlled release drug delivery semi-solids polymer excipient
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-021-1394-6
• Effect of converting ozonation to E-peroxone was studied on pharmaceutical removal.
关键词: Ozone Electro-peroxone Wastewater Quantitative structure activity relationship Advanced oxidation processes
Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG
《化学科学与工程前沿(英文)》 2012年 第6卷 第3期 页码 246-252 doi: 10.1007/s11705-012-1299-9
《医学前沿(英文)》 2022年 第16卷 第3期 页码 467-482 doi: 10.1007/s11684-021-0869-y
关键词: hepatocellular carcinoma cabozantinib primary resistance rapamycin
Effect of a promoter on the methanation activity of a Mo-based sulfur-resistant catalyst
Can LIN, Haiyang WANG, Zhenhua LI, Baowei WANG, Xinbin MA, Shaodong QIN, Qi SUN
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 88-94 doi: 10.1007/s11705-013-1301-1
Zhen Xiang, Yingyan Yu
《医学前沿(英文)》 2019年 第13卷 第1期 页码 24-31 doi: 10.1007/s11684-019-0679-7
关键词: immune checkpoint blockade sensitivity resistance data mining
Effect of ultraviolet irradiation and chlorination on ampicillin-resistant
Yuchen PANG,Jingjing HUANG,Jinying XI,Hongying HU,Yun ZHU
《环境科学与工程前沿(英文)》 2016年 第10卷 第3期 页码 522-530 doi: 10.1007/s11783-015-0779-9
关键词: antibiotic resistance Escherichia coli ampicillin resistance gene ultraviolet irradiation chlorination
标题 作者 时间 类型 操作
The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter
YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong
期刊论文
Prevalence and drug resistance characteristics of carbapenem-resistant Enterobacteriaceae in Hangzhou
null
期刊论文
Development of a multi-component drug from turmeric using central composite design
Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG
期刊论文
Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems
Ranvijay KUMAR, Kaushlendra SHARMA
期刊论文
Semi-solid materials for controlled release drug formulation: current status and future prospects
Michelle TRAN,Chun WANG
期刊论文
Identification of resistant pharmaceuticals in ozonation using QSAR modeling and their fate in electro-peroxone
期刊论文
Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery
Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG
期刊论文
Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular
期刊论文
Effect of a promoter on the methanation activity of a Mo-based sulfur-resistant catalyst
Can LIN, Haiyang WANG, Zhenhua LI, Baowei WANG, Xinbin MA, Shaodong QIN, Qi SUN
期刊论文
Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases
Zhen Xiang, Yingyan Yu
期刊论文